E. coli infection mechanism
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E. coli infection mechanism
E. coli infection mechanism. Immunofluorescence deconvolution micrograph of Escherichia coli bacteria (centre). Bacterial DNA (deoxyribonucleic acid) is blue. Actin protein filaments, which make up part of the cytoskeleton, are green. Here the actin filaments are causing protrusions on the cells membranes known as pedestals, which help this pathogenic bacteria to attach to intestinal cells. The pedestals cannot be formed without the presence of the host cell protein tyrosine kinase Abl2, which is red
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6307379
© DR DAN KALMAN/SCIENCE PHOTO LIBRARY
Actin Bacteria Bacterial Bacterium Confocal Micrograph Cytoskeleton Deconvolution E Coli Escherichia Coli Filament Filaments Fluorescent Immunofluorescence Immunofluorescent Infection Pathological Pathology Pedestal Protrusions Stain Stained Bio Chemistry Biochemical Cells Deoxyribonucleic Acid Light Micrograph Light Microscope Micro Biology Microbiological Pathogen Pedestals Protein
EDITORS COMMENTS
This print from Science Photo Library showcases the intricate mechanism behind an E. coli infection. In this immunofluorescence deconvolution micrograph, Escherichia coli bacteria take center stage, their presence highlighted by a striking blue hue representing their DNA. The green actin protein filaments, which form part of the cytoskeleton, add another layer of complexity to the image. What makes this image truly fascinating is the formation of pedestals on cell membranes caused by these actin filaments. These protrusions play a crucial role in enabling pathogenic bacteria like E. coli to attach themselves to intestinal cells and initiate infection. However, what sets this process apart is that these pedestals cannot be formed without the involvement of host cell protein tyrosine kinase Abl2 - depicted here in vibrant red. The combination of various staining techniques and fluorescent dyes has allowed scientists to capture this momentous interaction between bacterial pathogens and host cells with remarkable precision using light microscopy methods. This photograph not only highlights the beauty within biological processes but also serves as a valuable resource for researchers studying pathology, microbiology, biochemistry, and beyond. Science Photo Library continues its tradition of providing awe-inspiring visuals that bridge artistry and scientific discovery through images like this one – offering us a glimpse into the microscopic world where life's most intricate battles unfold before our eyes.
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